Hi! The python bindings fail to load libnotmuch with the new version of MacOS X (10.11). Running "afew", a tagger written in Python gives: Traceback (most recent call last): File "/usr/local/Cellar/afew/HEAD/libexec/bin/afew", line 9, in <module> load_entry_point('afew==0.0.0', 'console_scripts', 'afew')() File "build/bdist.macosx-10.9-x86_64/egg/pkg_resources.py", line 356, in load_entry_point """Return `name` entry point of `group` for `dist` or raise ImportError""" File "build/bdist.macosx-10.9-x86_64/egg/pkg_resources.py", line 2476, in load_entry_point except ValueError: File "build/bdist.macosx-10.9-x86_64/egg/pkg_resources.py", line 2190, in load parse_map = classmethod(parse_map) File "/Library/Python/2.7/site-packages/afew-0.0.0-py2.7.egg/afew/commands.py", line 27, in <module> from afew.Database import Database File "/Library/Python/2.7/site-packages/afew-0.0.0-py2.7.egg/afew/Database.py", line 23, in <module> import notmuch File "/usr/local/lib/python2.7/site-packages/notmuch/__init__.py", line 54, in <module> from .database import Database File "/usr/local/lib/python2.7/site-packages/notmuch/database.py", line 24, in <module> from .globals import ( File "/usr/local/lib/python2.7/site-packages/notmuch/globals.py", line 32, in <module> raise ImportError("Could not find shared 'notmuch' library.") ImportError: Could not find shared 'notmuch' library. Setting DYLD_FALLBACK_LIBRARY_PATH to /usr/local/lib (where libnotmuch4.dylib resides) did not help. As Eric Wang's response in this thread suggested http://stackoverflow.com/questions/32905322/oserror-dlopenlibsystem-dylib-6-image-not-found I've substituted nmlib = CDLL("libnotmuch.so.{0:s}".format(SOVERSION)) in globals.py nmlib = CDLL("/usr/local/lib/libnotmuch.{0:s}.dylib".format(SOVERSION)) This resolved the problem for me. With kind regards, Robert Künnemann